吳宛儒 副教授 - 元培視光系
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吳宛儒 副教授

姓 名 吳宛儒

性別 女

單位 視光系 級職 副教授
聯絡方式 E-Mail jwwu106104@mail.ypu.edu.tw
分機 8608

學 歷

國立台北科技大學工程科技研究所博士 (Ph.D.) – 2007
美國加州柏克萊大學視光學院視光科醫師 (O.D.) – 2003
美國加州柏克萊大學整合生物學學士 (B.A.) – 1998

經 歷
中臺科技大學視光系專任助理教授及副教授
台灣大學化學工程學系博士後研究員
嬌生視光學苑講師
中山醫學大學視光系專任講師

計畫
1. 以電腦模擬方式探討gamma D-型晶體蛋白在低酸鹼值與高溫度條件下之動態行為(NSC101-2113-M-166 -001 -MY2),主持人,國科會,2012/12/01
~2014/7/31。
2. 結合理論及實驗方法探討人類gamma D-型晶體蛋白之結構不穩定區域(MOST103-2113-M-166-001 -MY2),主持人,科技部,2014/08/01~2016/07/31。
3. 以殘留偶極耦合與分子動態模擬探討與白內障形成相關之人類gamma D-型晶體蛋白(MOST105-2113-M-166-001),主持人,科技部,2016/08/01 ~
2017/07/31。
4. 臺斯(SK)國合計畫-探討小分子物質及奈米粒子對於多胜肽類澱粉聚集行為之影響(MOST105-2923-E-002 -010 -MY3),共同主持人,科技部,2016/01/01~2018/12/31。
5. 結合核磁共振及分子模擬技術探討與白內障形成相關之人類Gamma D-型晶體蛋白之開展與其聚集之抑制(MOST 106-2113-M-166-001),主持人,科技部,2017/08/01~2018/07/31。

授課科目 目前授課課目:
眼科學、生理學、視覺科學、視能復健與管理

曾經授課課目:
驗光學相關課程及實驗、雙眼視覺學及實驗、臨床視光學、
低視力學、視光英文、視光論文導讀與寫作

近年發表著作

期刊論文
1. Lu NH, How SC, Lin CY, Tsai SL, Bednarikova Z, Fedunova D, Gazova D , Wu JW, Wang SS. “Examining the Effects of Dextran-Based Polymer-Coated Nanoparticles on Amyloid Fibrillogenesis of Human Insulin,” Colloids Surf B Biointerfaces. 2018 (accepted and in press)
2. How SC, Cheng YH, Lo CH, Lai JT, Lin TH, Bednarikova Z, Antosova A, Gazova Z, Wu JW, Wang SS. “Exploring the effects of methylene blue on amyloid fibrillogenesis of lysozyme,” Int J Biol Macromol. 2018;119:1059-1067. SCI, IF= 3.67
3. Li CT, How SC, Chen ME, Lo CH, Chun MC, Chang CK, Chen WA, Wu JW, Wang SS. “Effects of glycation on human γd-crystallin proteins by different glycation-inducing agents,” Int J Biol Macromol. 2018;118(Pt A):442-451. SCI, IF= 3.67
4. Ulicna K, Bednarikova Z, Hsu WT, Holztragerova M, Wu JW, Hamulakova S, Wang SS, Gazova Z. “Lysozyme amyloid fibrillization in presence of tacrine/acridone-coumarin heterodimers,” Colloids Surf B Biointerfaces. 2018;166:108-118. SCI, IF=3.89
5. Kuo CT, Chen YL, Hsu WT, How SC, Cheng YH, Hsueh SS, Liu HS, Lin TH, Wu JW, Wang SS. “Investigating the effects of erythrosine B on amyloid fibril formation derived from lysozyme,” Int J Biol Macromol. 2017;98:159-168. SCI, IF=3.67
6. Chang CK, Wang SS, Lo CH, Hsiao HC, Wu JW. “Investigation of the early stages of human γD-crystallin aggregation process,” J Biomol Struct Dyn. 2016;19:1-13. SCI, IF=3.12
7. Wu JW, Huang CM, Hou SY. “A Novel RpoD Complementary System to stabilize plasmid and protein production in recombinant Escherichia coli,” Biotechnology and Bioprocess Engineering. 2015; 20(3):396–402. SCI, IF=1.16
8. Wu CC, Wu JW. “Comparative Analysis of Refractive Outcomes and Blink Rates Using Projector and Computer VA Charts,” Central Taiwan Journal of Humanities and Social Sciences. 2015;25(3):55-84.
9. Wu JW, Chen ME, Wen WS, Chen WA, Li CT, Liu HS, Wang SS. "Comparative
Analysis of Human γD-Crystallin Aggregation under Physiological and Low pH Conditions, " PLoS One. 2014 Nov; 9(11):e112309. SCI, IF=2.81
10. Wu JW, Liu KN, Lai CM, Liu HS, Wang SS. "Carnosine's Effect on Lysozyme Amyloid Fibril Formation and Induced Cytotoxicity," PLoS One. 2013 Dec; 8(12): e81982. SCI, IF=2.81
11. Zhou JL, Liu HL, Wu JW, Tsao CW, Chen WH, Liu KT, Ho Y. “Combining structure-based pharmacophore and in silico approaches to discover novel selective serotonin reuptake inhibitors,” Chem Biol Drug Des. 2013 Dec; 82(6), 705-17. SCI, IF=2.40
12. Wu JW, Kao CY, Lin LT, Wen WS, Lai JT, Wang SS. “Human γD-Crystallin Aggregation Induced by Ultraviolet C Irradiation is Suppressed by Resveratrol,” Biochemical Engineering Journal. 2013 Aug; 78:189– 197. SCI, IF=2.89
13. Lin PH, Tsai CW, Wu JW, Ruaan RC, Chen WY. "Molecular Dynamics Simulation of Induced-Fit Binding Process of DNA Aptamer and L-Argininamide," Biotechnol J. 2012 Nov;7(11):1367-75. SCI, IF=3.65
14. Liao HS, Wu JW, Liu HS, Zhou ZL, Zhao JH, Chen W, Tsai WB, Ho Y. “Pharmacophore modeling and virtual screening to design the potential influenza virus endonuclease inhibitors”, J Chin Chem Soc. 2012 Nov;59(11):1430-1438. SCI, IF=0.94
15. Chen YC, Lin WT, Wu JW, and Liu HS. “Efficient lysozyme refolding at a high final concentration and a low dilution factor,” Process Biochem. 2012 Jun;47(12):1883-1888. SCI, IF=2.50
16. Wu JW and Liu HL. “In silico Investigation of the Disease-associated Retinoschisin C110Y and C219G Mutants,” J Biomol Struct Dyn. 2012 Apr;29(5):937-59. SCI, IF=3.12
17. Zhou ZL, Zhao JH, Liu HL, Wu JW, Liu KT, Chuang CK, Tsai WB, Ho Y.
“The possible structural models for polyglutamine aggregation: a molecular dynamics simulations study,” J Biomol Struct Dyn. 2011 Apr;28(5):743-58. SCI, IF=3.12
18. Wu JW, Lu SH, Liu HL, Zhao JH, Liu KT, Chuang CK, Lin HY, Tsai WB, Ho Y. “The discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies,” J Biomed Sci. 2011 Jan;18:8. SCI, IF=2.80
19. Lin YF, Zhao JH, Liu HL, Wu JW, Chuang CK, Liu KT, Lin HY, Tsai WB, Ho Y. “Insights into the structural stability and possible aggregation pathways of the LYQLEN peptides derived from human insulin,” J. Taiwan Inst. Chem. Eng. 2010 Nov;1876-1070. SCI, IF=4.22
20. Chang LK, Zhao JH, Liu HL, Wu JW, Chuang CK, Liu KT, Chen JT, Tsai WB, HoY.“The importance of steric zipper on the aggregation of the MVGGVV peptide derived from the amyloid beta peptide,” J Biomol Struct Dyn. 2010 Aug;28(1):39-50. SCI, IF=3.12
21. Zhao JH, Yang CT, Wu JW, Tsai WB, Lin HY, Fang HW, Ho Y, Liu HL.
“RING domains functioning as E3 ligases reveal distinct structural features: a molecular dynamics simulation study,” J Biomol Struct Dyn. 2008 Aug;26(1):65-74. SCI, IF=3.12
22. Wang SS, Wu JW, Yamamoto S, Liu HS. “Diseases of protein aggregation and the hunt for potential pharmacological agents,” Biotechnol J. 2008 Feb;3(2):165-92. Review. SCI, IF=3.65
23. Lieu VH, Wu JW, Wang SS, Wu CH.“Inhibition of amyloid fibrillization of hen egg-white lysozymes by rifampicin and p-Benzoquinone,” Biotechnol Prog. 2007 May-Jun;23(3):698-706. Epub 2007 May 11. SCI, IF=1.99
24. Evans DJ, Maltseva IA, Wu J, Fleiszig SM. “Pseudomonas aeruginosa internalization by corneal epithelial cells involves MEK and ERK signal transduction proteins,” FEMS Microbiol Lett. 2002 Jul;213(1):73-9. SCI, IF=1.77

研討會論文
25. Chen YF, Chang CJ, Wu JW, “The Effect of Smartphone Usage on Accommodative Function”, The 14th Asia-Pacific Conference on Vision and the 3rd China Vision Science Conference, Hangzhou, China, July 2018.
26. Lo SY, Wu R, Tsai CY, Wu JW, “Analysis Of Eye-related Responses from the Biocompatibility of Multipurpose Solution and Soft Lens combinations”, International Conference on Biomedical Sciences, Taichung, Taiwan, June 2018.
27. Lin CY, Lu NH, How SC, Gazova Z, Wu JW, Wang SS, “Effects of Dextran-Based Polymer-Coated Nanoparticles on Amyloid Fibrillogenesis of Human Insulin”, 2018 BEST Conference and International Symposium on Biotechnology and Bioengineering, Taipei, Taiwan, June 2018.
28. Lu JH, Wang SS, Wu JW, “Seeking the Inhibitory Molecules Toward the Ultraviolet C-Induced Aggregation of Human γD-Crystallin Protein”, 2018 BEST Conference and International Symposium on Biotechnology and Bioengineering, Taipei, Taiwan, June 2018.
29. Wu JW, Hsueh SS, Wang SS, Lin TH, “Examining the Unfolding/Aggregating Behavior of Human γD-Crystallin – Deciphering the Mechanism(s) of Cataract Formation”, The 23rd Symposium of Young Asian Biological Engineers’ Community (YABEC 2017), Xi’An, China, October 2017.
30. Hsueh SS, Wang SS, Lin TH, Wu JW, “Using the Residual Dipolar Couplings Technique Combined with Chemical Unfolding to Probe for the Structural Stability of Human Gamma-D Crystallin Associated with Cataract”, The 23rd Symposium of Young Asian Biological Engineers’ Community (YABEC 2017), Xi’An, China, October 2017.
31. Hsueh SS, Wang SS, Lin TH, Wu JW, “Exploring the Structural Stability of Human Gamma-D Crystallin Proteins Using the Residual Dipolar Couplings Technique Combined with Chemical Unfolding”, 2017 BEST Conference and International Symposium on Biotechnology and Bioengineering, Yunlin, Taiwan, June 2017.
32. Hsu WT, Wu JW, Wang SS, “Exploring the Inhibitory Activity of Brilliant Blue G Toward the Formation of Amyloid Fibrils Derived from Lysozyme”, 2017 BEST Conference and International Symposium on Biotechnology and Bioengineering, Yunlin, Taiwan, June, 2017. [1st place in English Oral Session]
33. 陳佳宜, 吳怡璁, 吳宛儒, “市售軟式彩拋隱形眼鏡與市售多功能藥水組合對眼睛的生物相容性影響”, 2017年功能性材料研討會暨科技部專題研究計畫成果發表會, 臺南, 臺灣, 六月2017年. [佳作]
34. Wu JW, Hsueh SS, Lin TH, Wang SS, “Examining the Structural Stability of Human D-Crystallin Protein Associated with Cataract”, The 22nd Symposium of Young Asian Biological Engineers' Community (YABEC 2016), Miyazaki, Japan, October 2016.
35. Lo SC, Wang SS, Wu JW, “Exploring the Structural Stability of Human gammaD-Crystallin by Single-point Mutations”, 2016 BEST Conference and International Symposium on Biotechnology and Bioengineering, Chungli, Taiwan, June 2016.
36. Hsueh SS, Wang SS, Wu JW, Lin TH, “Using Nuclear Magnetic Resonance Spetroscopy to Examine the Structural Stability of Human GammaD Crystallin Associted with Cataract”, 2016 BEST Conference and International Symposium on Biotechnology and Bioengineering, Chungli, Taiwan, June 2016.
37. Duan HY, Wang SS, Dai CA, Wu JW, “The Development of Artificial Cornea Using Silicone-Hydrogel Material”, 2016 BEST Conference and International Symposium on Biotechnology and Bioengineering, Chungli, Taiwan, June 2016.
38. Wu JW, Chen WA, Chung MC, Wang SS, “Investigating the Influence of Quercetin on the UV-C Irradiation-Induced Aggregation of Human γD-Crystallin Protein”, The 62th Annual Meeting of the Taiwan Institute of Chemical Engineers, Kaohsiung, Taiwan, November 2015.
39. Wu CC, Wu JW, “Refractive Results and Blink Rates during Refraction with Projector and Computerized VA Charts”, The 20th APOC Conference, Kuala Lumpur, Malaysia, October 2015.
40. Wu JW, Chang CK, Liu HS, Wang SS, “Understanding the Structural Transition and Possible Amyloid-Fibril Formation Mechanism of Human γD-Crystallin Associated with Cataract”, 21st Young Asian Biochemical Engineers’ Community (YABEC 2015), Chuncheon, Korea, October 2015.
41. Chang CK, Wang SS, Wu JW, “Molecular Insights into the Structural Alteration and Possible Amyloid-Fibril Formation Pathway of Human γD-Crystallin Proteins”, 2015 BEST Conference and International Symposium on Biotechnology and Bioengineering, Taipei, Taiwan, June 2015.
42. Chen G, Wang SS, Wang MJ, Wu JW, “Synthesis and characterization of p(2-hydroxyethyl methacrylate-co-methacrylic acid) hydrogel”, 2015 BEST Conference and International Symposium on Biotechnology and Bioengineering, Taipei, Taiwan, June 2015. [Outstanding Award in English Oral Session]
43. Chang CK, Wu JW, Wang SS, “Examining the Unfolding Pathway of Human γD-Crystallin under Acidic Conditions by Molecular Dynamics Simulations,” 20th Young Asian Biochemical Engineers' Community (YABEC) symposium, November 2014. [Outstanding Award in Poster Session]
44. Chen WA, Wen WS, Wu JW, Wang SS, “Examining the Aggregation Behavior of the Wild Type Human D-Crystallin Proteins under Different pH Conditions,” 19th Annual BEST Conference on Biotechnology and Bioengineering, June 2014 [1st place in English Oral Session]
45. Wu JW, Wen WS, Chen WA, Wang SS, “Investigating the Aggregation Behavior of Human γD-Crystallin under Physiological and Low pH Conditions,” International Congress on Chemical, Biological, and Environmental Sciences, Kyoto, Japan, May 2014.
46. Huang PY, Wu JW, Lin TH, Wang SS, “Probing the Structural stability of Human γD-crystallin by NMR Spectroscopy,” 60th Annual Meeting of Taiwan Institute of Chemical Engineering, November 2013.
47. Chen WA, Liu KN, Wu JW, Wang SS, “Exploring Carnosine’s Mechanism of Action in Amyloid Fibril Inhibition,” 60th Annual Meeting of Taiwan Institute of Chemical Engineering, November 2013 [Honorable Mention in English Oral Session].
48. Li CT, Wu JW, Wang SS, “Examining the Influence of Glycation on Human γD-Crystallin Associated with Cataract,” 18th Annual BEST Conference on Biotechnology and Bioengineering, June 2013 [Honorable Mention].
49. Chen WA, Liu KN, Wu JW, Wang SS, “Examining the Mechanism of Carnosine’s Inhibitory Activity Toward Amyloid Fibrillogenesis and Induced Cytotoxicity of Lysozyme,” 18th Annual BEST Conference on Biotechnology and Bioengineering, June 2013 [1st place in English Oral Session]
50. Chen MJ, Wu JW, and Liu HL, “Discovery of potential Acyl-coenzyme A: cholesterol acyltransferase 1/2 and dual inhibitors via pharmacophore modeling and database screening,” 58th Annual Meeting of Taiwan Institute of Chemical Engineering, October 2011. [Honorable Mention]
51. Wu JW and Liu HL, “An in silico study of the structural changes in retinoschisin mutants,” 10th Ube International Bioseparation Symposium, Ube, Japan, December 2010.
52. Wu JW and Liu HL, “The study of structural changes in retinoschisin mutants by molecular dynamics simulations and in silico predictions,” The 13th Asia Pacific Confederation of Chemical Engineering Congress, Taipei, Taiwan, October 2010.
53. Wu JW and Liu HL, “Investigating the protein stability and aggregation propensity of the retinoschisin mutants,” 15th Conference on Biochemical Engineering, Tainan, Taiwan, June 2010.
54. Wang SS and Wu JW, “Protein Conformational Diseases and Relevant Potential Pharmacological Agents,” Sixth Ube International Bioseparation Symposium, Ube, Japan, November 2006.

個人證照(書)
參考文件
1.美國國家考試(NBEO)認證臨床視光醫師 (Licensed Optometrist)
2.美國國家考試(NBEO)療藥認證 (TPA certification)

業界經驗與服務
1.台北市驗光師公會 學術顧問
2.中華生化工程學會 國際研討會學術委員
3.美國南加州COSCO 視光科醫師
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